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Ulcerative colitis in sisterly practice

DOI: https://doi.org/10.29296/25879979-2021-06-13
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Issue: 
6
Year: 
2021

V.V. Skvortsov, G.I. Malyakin, E.A. Goliyeva Volgograd State Medical University, Russian Health Ministry

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease caused by immune disorders, mental disorders, genetics, and other factors. Its main clinical manifestations are accompanied by abdominal pain, diarrhea, bloody stools, weight loss, etc. A distinctive feature of ulcerative colitis from Crohn’s disease is its limitation by the large intestine, as well as the limited inflammation of the mucous membrane.The disease affects any age group from infants to the elderly, with a maximum incidence rate between the ages of 15 to 30 years and between 50 and 70 years. seriously affects human health and quality of life because of its long duration and repeated attacks, and also has the risk of developing colorectal cancer. The disease violates the quality of life and leads to disability.The article presents the causes of ulcerative colitis, describes the mechanisms for the development of pathological changes in the intestine. Designated principles of patient management, taking into account the severity and tactics of rational drug therapy.
Keywords: 
nonspecific ulcerative colitis
inflammatory bowel disease
gene NOD2/CARD15
PAMP
WCE (Wireless capsule endoscopy)
calprotectin

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