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Trehalose as a special sugar

DOI: https://doi.org/10.29296/25879979-2023-04-08
Issue: 
4
Year: 
2023

Khoroshinina
Federal State Budgetary Educational Institution of Higher Education «St. Petersburg State Pediatric Medical University» of the Ministry of Health of the Russian Federation

In recent decades, a significant number of scientific papers have been published devoted to the study of the specific physical and chemical properties of a special sugar – trehalose and its role in living systems. Trehalose is widespread in nature. This unique disaccharide protects proteins and cell membranes from inactivation or denaturation caused by various stress conditions, including desiccation, dehydration, heat, cold, oxidation, heat shock, hypoxia, prolonged absence of oxygen. Trehalose enhances autophagy, protecting cells of organisms from various stress influences; is a powerful modifier of abnormal protein accumulation in human neurodegenerative diseases; has a favorable effect on vascular endothelium; positively affects metabolic processes in the human body, including type 2 diabetes - and this is only a small part of the positive effects that trehalose has on the body. It is well known that anti-aging medicine is aimed at slowing down aging processes and postponing the manifestation of age-dependent diseases, but so far there are no drugs that can reliably slow down the aging process in humans. Nature has created the molecule trehalose as a unique molecular structure that supports life on our planet and may have given mankind a chance to live longer.
Keywords: 
trehalose
geroprotectors
neurodegenerative diseases
prevention of aging.

References: 
  1. Анисимов В.Н., Попович И.Г. Геропротекторы/ в кн. Гериатрия: Руководство для врачей, под ред Л.П. Хорошининой. М.: Геотар-Медиа, 2019; 34–41.
  2. Красникова Л.В., Гунькова П.И., Савкина О.А. Общая и пищевая микробиология: Учеб. пособие. Часть II. СПб.: Университет ИТМО, 2016 127 с.
  3. Феофилова Е. П, Усов А. И., Мысякина И. С. и др. Трегалоза: особенности химического строения, биологические функции и практическое значение. Микробиология, 2014; 83(3): 271–283.
  4. Шиповская А.А., Курбатова И.В., Селивёрстов П.В. и др. Клинические особенности неалкогольного стеатогепатита у больных с разным гликемическим статусом. Медицинский Совет. 2021; (5): 68–74. https:// doi.org/10.21518/2079-701X-2021-5-68-74.
  5. Малярчук Б.А., Деренко М.В. Полиморфизм гена трегалазы (TREH) у коренного населения Сибири. Вавиловский журнал генетики и селекции. 2017;21(8):964–968. DOI 10.18699/VJ17.320.
  6. Backus K.M., Boshoff H.I., Barry C.S. et al. Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis. Nat Chem Biol. 2011. Vol. 7. P. 228–235.
  7. Casarejos M.J., Solano R.M., Gómez A. et al. The accumulation of neurotoxic proteins, induced by proteasome inhibition, is revered by trehalose, an enhancer of autophagy, in human neuroblastoma cells. Neurochem Int. 2011 Vol.58. P.512–520.
  8. Castillo K., Nassif M., Valenzuela V. et al. et al. Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons. Autophagy. 2013. Vol.9. P.1308–1320.
  9. Chen Q., Haddad G.G. Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals. J Exp Biol. 2004. Vol.207 (Pt 18) P. 3125–3129.
  10. Chen Z.Z., Wang C.M., Lee G.C. et al. Trehalose attenuates the gait ataxia and gliosis of spinocerebellar ataxia type 17 mice. Neurochem Res. 2015 Vol.40. P. 800–810.
  11. Clark A.E., Sabalza M., Gordts P.L. et al. Human Cytomegalovirus Replication Is Inhibited by the Autophagy-Inducing Compounds Trehalose and SMER28 through Distinctively Different Mechanisms. J Virol. 2018. Vol.26. № 92. P. e02015-17.
  12. Шубина О.Г. Полидекстроза – многофункциональный углевод для создания низкокалорийных и обогащенных продуктов. Пищевая промышленность. 2005$ (5): 28–31.
  13. Emanuele E. Can trehalose prevent neurodegeneration? Insights from experimental studies. Curr Drug Targets. 2014. Vol.15. P. 551–557.
  14. Effect of trehalose on the interaction of Alzheimer’s Aβ-peptide and anionic lipid monolayers. Biochim Biophys Acta. 2011;1808(1):26–33.
  15. Fernandez O., Bethencourt L., Quero A. et al. Trehalose and plant stress responses: friend or foe? Trends Plant Sci. 2010. V. 15. P. 409–417.
  16. Hill-Bator A, Misiuk-Hojło M, Marycz K, Grzesiak J. Trehalose-based eye drops preserve viability and functionality of cultured human corneal epithelial cells during desiccation. Biomed Res Int. 2014:292139. doi: 10.1155/2014/292139.
  17. Honda Y., Tanaka M., Honda S. Trehalose extends longevity in the nematode Caenorhabditis elegans. Aging Cell. 2010. Vol.9. P. 558–569.
  18. Ichihara H., Kuwabara K., Matsumoto Y. Trehalose liposomes induce apoptosis of breast tumor cells in vitro and in vivo. Biochem Biophys Res Commun. 2020. Vol. 19. P.505–512.
  19. Mizote A., Yamada M., Yoshizane C., et al. Daily Intake of Trehalose Is Effective in the Prevention of Lifestyle-Related Diseases in Individuals with Risk Factors for Metabolic Syndrome. J Nutr Sci Vitaminol (Tokyo). 2016;62(6):380–387. https://doi.org/10.3177/jnsv.62.380.
  20. Kaplon R.E., Hill S.D., Bispham N.Z. et al. Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults. Aging (Albany NY). 2016. Vol. 8. P. 1167–1183.
  21. J Microbiol Biotech Food Sci / Faik et al. 2019: 8 (6) 1298–1302. https://doi.org/10.15414/jmbfs.2019.8.6.1298-1302.
  22. Kumar S.K., Prakash T., Vetriselvan M., Mani K.P. Trehalose protects the endothelium from cadmium-induced dysfunction. Cell Biol Int. 2021. Vol.45. P. 957–964.
  23. Kyryakov P., Beach A., Richard V.R. et al. Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration. Front Physiol. 2012. Vol. 6. P. 256.
  24. Lee H.J., Yoon Y.S., Lee S.J. Mechanism of neuroprotection by trehalose: controversy surrounding autophagy induction. Cell Death Dis. 2018. Vol.15. № 9. P. 712.
  25. Lin L.S., Kayasuga-Kariya Y., Nakamura S. et al. Co-lyophilized Aspirin with Trehalose Causes Less Injury to Human Gastric Cells and Gastric Mucosa of Rats. Dig Dis Sci. 2016. Vol.61. P. 2242–2251.
  26. Luyckx J., Baudonin C. Trehalose: an intriguing disaccharide with potential for medical application in ophthalmology. Clin. Ophtalmol. 2011. V. 5. P. 577–581.
  27. Григорьева Н.Н., Пейч М.Е., Шадричев Ф.Е. Эффективность трегалозы в лечении синдрома «сухого глаза» у больных сахарным диабетом. Офтальмологические ведомости. 2016; 9(2): 19–24.
  28. Mizote A. et al. Daily Intake of Trehalose Is Effectivein the Prevention of Lifestyle-Related Diseases in Individuals with Risk Factors for Metabolic Syndrome. J Nutr Sci Vitaminol (Tokyo). 2016 Vol.62. P.380–387.
  29. Moon J.E., Heo W., Lee S.H. et al. Trehalose Protects the Probiotic Yeast Saccharomyces boulardii against Oxidative Stress-Induced Cell Death. J Microbiol Biotechnol. 2020. Vol. 28. № 30. P. 54–61.
  30. Noorasyikin M.A., Azizan E.A., Teh P.C. et al. Oral trehalose maybe helpful for patients with spinocerebellar ataxia 3 and should be better evaluated. Parkinsonism Relat Disord. 2020. Vol.70. P.42–44.
  31. Patist A., Zoerb H. Preservation mechanisms of trehalose in food and biosystems. Colloids and Surfaces B: Biointerfaces. 2005. V. 40. P. 107–113.
  32. Qiaofang Chen , Gabriel G Haddad Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals. J Exp Biol. 2004. Vol.207(Pt 18). P. 3125–3129.
  33. Rashid Q., Abid M., Gupta N. et al. Polysulfated trehalose as a novel anticoagulant agent with dual mode of action. Biomed Res Int. 2015 :630482. doi: 10.1155/2015/630482.
  34. Richards A. B., Krakowka S., Dexter L. B., Schmid H., Wolterbeek A. P. M., Waalkens-Berendsen D. H., Shigoyuki A., Kurimoto M. Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies. Food Chem Toxicol . 2002. Vol.;40. P. 871–898.
  35. Richtmyer N.K. Methods in Carbohydrate Chemistry / Eds. Whistler R.L. and Wolfrom M.L. NY–L.: Academic Press Inc., 1962. V. 1. P. 370–372.
  36. Schiraldi C., Di Lernia I., De Rosa M. Trehalose production: exploiting novel approaches. Trends Biotechnol. 2002. Vol.20. P. 420–425.
  37. Arguelles JC. Physiological roles of trehalose in bacteria and yeasts: a comparative analysis. Arch Microbiol. 2000 Oct;174(4):217–224.
  38. Matsuo T. Trehalose protects corneal epithelial cells from death by drying. Br J Ophthalmol. 2001 May;85(5):610–612. https://doi.org/10.1136/bjo.85.5.610.
  39. Stachowicz A., Wiśniewska A., Kuś K. et al. The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice. Int J Mol Sci. 2019. Vol.28. № 20. P. 1552.
  40. Thammahong, A., Puttikamonkul, S., Perfect, J. R., Brennan, R. G., & Cramer, R. A. (2017). Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development. Microbiology and Molecular Biology Reviews, 81(2). doi:10.1128/mmbr.00053-16. 10.1128/MMBR.00053-16.
  41. Торшин И.Ю., Аполихина И.А., Громов А.Н., Громова О.А. Свойства D-маннозы: противовоспалительный и противоопухолевый эффекты. Экспериментальная и клиническая урология 2020;(2):164–170. DOI: 10.29188/2222-8543-2020-12-2-164-170.
  42. Wiggers H.A.L. Untersuchung über das Mutterkorn, Secale cornutum. Ann. Pharmacie. 1832. V. 1. № 2. P. 129–182.
  43. Yaribeygi H., Yaribeygi A., Sathyapalan T., Sahebkar A. Molecular mechanisms of trehalose in modulating glucose homeostasis in diabetes. Diabetes Metab Syndr. 2019. Vol.13. P. 2214–2218.
  44. Zhang Y., Brian J., DeBosch Using trehalose to prevent and treat metabolic function: effectiveness and mechanisms //Curr Opin Clin Nutr Metab Care . 2019. Vol.22. P. 303–310.
  45. Zhang Y., DeBosch B.J. Microbial and metabolic impacts of trehalose and trehalose analogues. Gut Microbes. 2020. Vol. 2. №.11. P. 1475–1482.