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Children’s problems of coronavirus infection (discussion of the latest data)

DOI: https://doi.org/ 10.29296/25879979-2022-02-09
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Issue: 
2
Year: 
2022

K.I. Grigoriev(1), O.М. Radchenko(2), Ya. E. Shirobokov(3) 1-Pirogov Russian National Research Medical University, Moscow 2-Regional Children’s Clinical Hospital № 2, Voronezh 3-Samara State Medical University of the Ministry of Health of the Russian Federation, Samara

The pandemic of a new severe infection, declared by the World Health Organization last year, continues to develop. To a certain extent, the epidemic has affected the children’s population. Pediatricians for the first time faced with an incredible situation when adults get sick more severely than children. Summary data are presented on the results of clinical observations in the Tushinskaya Children’s City Clinical Hospital in Moscow, and on the results of scientific sources. The article sums up the results of the latest observations regarding the development of a new disease, its diagnosis, therapeutic possibilities using modern medicines. The role of the use of standards is emphasized, in particular, the clinical recommendations of the Ministry of Health of Russia, the 14th version of which has just been posted on the website of the ministry

Keywords: 
children
COVID-19
SARS-CoV-2
clinical features
prevention
“red” zone



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References: 
  1. Supotnitsky M.V. The COVID-19 pandemic as an indicator of «blank spots» in epidemiology and infectious pathology. Bulletin of the RCB Protection Troops. 2020. Vol. 4. No. 3: 338–373
  2. https://doi.org/10.35825/2587-5728-2020-4-3-338-373 (In Russ.)
  3. Kudlay DA, Shirobokov YE, Gladunova EP, Borodulina EA Diagnosis of COVID-19. Methods and Problems of Detection of SARS-COV-2 Virus in Pandemic Conditions. Vrach. 2020; 31(8): 5–10.
  4. Gaythorpe K.A. M., Bhatia S., Mangal T., et al. Children’s role in the COVID‑19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility. Nature. 2021; 11: 13903. https://doi.org/10.1038/s41598-021-92500-9
  5. Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020; 181: 271–280.
  6. Synowiec A, Szczepanski A, Barreto-Duran E, et al. severe acute respiratory syndrome coronavirus 2 (SARSCoV-2): a systemic infection. Clin Microbiol Rev. 2021. 34:e00133-20. https://doi.org/10.1128/CMR.00133-20.
  7. Logunov DY, Dolzhikova IV, Shcheblyakov DV, et al. Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia. Lancet. 2021; vol. 397, issue 10275: 671-681. https://doi.org/10.1016/ S0140-6736(21)00234-8
  8. Rumyantsev A.G. Coronavirus infection COVID-19. Scientific challenges and possible ways of treatment and prevention of the disease. Russian Rossiyskiy zhurnal detskoy gematologii i onkologii/Journal of Pediatric Hematology and Oncology. 2020; 7 (3): 47-53. https://doi.org/10.21682/2311-1267-2020-7-3-47–53 (in Russ)
  9. Huang C., Wang Y., Li X., et al Сlinical features of patients infected with the new coronavirus 2019 in Wuhan, China. The Lancet. 2020; 395: 497–506.
  10. Martin B, DeWitt PE, Russell S et al. Characteristics, Outcomes, and Severity Risk Factors Associated With SARS-CoV-2 Infection Among Children in the US National COVID Cohort Collaborative. JAMA Netw Open. 2022;5(2): e2143151. doi: 10.1001/jamanetworkopen.2021.43151.
  11. Ilyenkova N.A., Konurkina N.S., Sokolovskaya E.S., et al Clinical and laboratory features of the course of the pathology of the lower respiratory tract caused by a new coronavirus infection and pneumonia of bacterial etiology in children. Pacific Medical Journal. 2021; 4:56–61. doi: 10.34215/1609-1175-2021-4-56–61 (in Russ)
  12. Riphagen S., Gomez X., Gonzalez-Martinez C., et al. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020;395(10237):1607-8. DOI: 10.1016/S0140-6736(20)31094-1.
  13. DeBiasi R.L., Song X., Delaney M. et al. Severe COVID-19 in children and young adults in the Washington, DC Metropolitan Region. J Pediatr 2020;223:199–203.e1. DOI: doi: 10.1016/j.jpeds.2020.05.007.
  14. Osmanov I.M., Mazankova L.N., Samitova E.R. et al. New coronavirus infection (COVID-19) in children. Pediatrician’s Practice 2021;(3):8–11. (In Russ.)
  15. Preston L.E., Chevinsky J.R., Kompaniyets L., et al Characteristics and Disease Severity of US Children and Adolescents Diagnosed With COVID-19. JAMA Netw Open. 2021; 4 (4): e215298. doi:10.1001/jamanetworkopen. 2021.5298
  16. Esfehani RJ, Aelami MH, Kalat AR, et al. SARS-CoV-2 Liability: The Hidden Mystery Behind Its Presentation in Children. Adv Exp Med Biol. 2021; т1353:225–241. doi: 10.1007/978-3-030-85113-2-13
  17. Kaleda M.I., Nikishina I.P., Fedorov E.S., et al. Coronavirus Disease 2019 in Children: Lessons from Pediatric Rheumatology. Scientific and practical rheumatology. 2020; 58 (5): 469-479. https://doi.org/10.47360/1995-4484-2020-469–479 (in Russ)
  18. Belhadjer Z, Méot M, Bajolle F, et al. Acute heart failure in multisystem inflammatory syndrome in children (MIS-C) in the context of global SARS-CoV-2 pandemic. Circulation. 2020. Vol.142 (5): 429–436. https://doi.org/10.1161/CIRCULATIONAHA.120.048360
  19. Salvatore S., Marinoni M, Agosti М. Additional Concerns Regarding Children With Coronavirus Disease 2019. JAMA Pediatr. 2020; 174(12):1217–1218. doi: 10.1001/jamapediatrics.2020.2922
  20. Namazova-Baranova L.S. Coronavirus infection (COVID-19) in children. Pediatric Pharmacology. 2020; 17 (3): 162–168. doi: 10.15690 / pf.v17i3.2121) (in Russ)
  21. Temporary guidelines. Prevention, diagnosis and treatment of a new coronovirus infection (COVID-19). Version 14 (12/27/2021) (in Russ)
  22. Zhu H., Wang L., Fang C., et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl. Pediatr. 2020; 9 (1): 51–60. DOI: 10.21037/tp.2020.02.06
  23. Banerjee M, Pal J, Mondal T, et al. Clinical Profile and Short-Term Outcome of SARS-CoV-2-Infected Neonates from a Government Medical College in West Bengal, India. J Trop Pediatr. 2022;68(1): fmac002. doi: 10.1093/tropej/fmac002
  24. Huang Z, Xia S, Mei S, et al. Integrated Analysis Reveals the Characteristics and Effects of SARS-CoV-2 Maternal-Fetal Transmission. Front Microbiol. 2022; 13:813187. doi: 10.3389/fmicb.2022.813187.
  25. Ludvigsson J.F. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatrica 2020; 109:1088-1095. doi: 10.1111/apa.15270.
  26. Bussières E-L., Malboeuf-Hurtubise C., Meilleur A., et al, PRISME-COVID Team. Consequences of the COVID-19 Pandemic on Children’s Mental Health: A Meta-Analysis. Front. Psychiatry, 01 December 2021| https://doi.org/10.3389/fpsyt.2021.691659
  27. Fratev F. The N501Y and K417N mutations in the spike protein of SARS-CoV-2 alter the interactions with both hACE2 and human derived antibody: A Free energy of perturbation study. Journal of Chemical Information and Modeling. doi: 10.1021/acs.jcim.1c01242