Журнал включен в российские и международные библиотечные и реферативные базы данных
РИНЦ (Россия)
EBSCO
Ulrichsweb

Prevention of accelerated aging and «diseases of civilization» with the help of natural geroprotectors BioChaga and BioDihydroquercetinA.N. Kovalchuk

DOI: https://doi.org/10.29296/25879979-2022-03-07
Issue: 
3
Year: 
2022

O.N. Usolceva, candidate of medical sciences. Irkutsk State Medical University. E-mail: [email protected]

Purpose of the study. Systematization of the obtained literature data on the mechanisms of aging and the administration of BioChaga and Biodihydroquercetin in different categories of persons. Based on this, description the mechanism of action and effectiveness of administration of BioChaga, Biodihydroquercetin of the trademark «Baikal Legend» for prevention of cardiovascular, cerebrovascular, oncological diseases and type 2 diabetes mellitus, as age-related diseases. Drawing relationship between accelerated aging and «diseases of civilization», determination of BioChaga and BioDihydroquercetin role for prevention of these phenomena and evaluation of their impact on life quality and integral health indicators in elderly men and women. Material and methods. Completed: analysis of 10 Russian and 5 foreign publications. Reflected: the composition, pharmacological properties, mechanism of action of BioChaga, BioDihydroquercetin of the trade mark «Baikal Legend», their administration for prevention of cardiovascular, cerebrovascular, oncological diseases, diabetes mellitus, their complications. We evaluated the contribution of BioDihydroquercetin (study at the Irkutsk State Medical University) in elderly people who are engaged in a health group and have an aggravated cardiovascular history. Results. BioChaga and BioDihydroquercetin have pronounced antioxidant, antiradical and anti-inflammatory properties, as well as high bioavailability. This makes them effective in combating excess free radicals and confirms their effectiveness in slowing down the aging process at the cellular level, according to the free radical theory of aging. In elderly patients, those involved in health groups while taking BioDihydroquercetin for 2 months showed a significant decrease in body weight by 1 kg (p=0.0004); BMI - by 2.6 kg/m2 (p=0.0005); SBP - by 3 mm Hg. (p=0.0092); DBP - by 10 mm Hg (p=0.0262); fat mass - by 1.1% (p=0.0262). There was a statistically significant increase in integral health indicators: FFI - by 2% (p=0.0147); mental reserves - by 10% (p=0.0278) and general reserves - by 2.1% (p=0.0279). Administration of BioChaga and BioDihydroquercetin reduces influence of risk factors for cardiovascular and cerebrovascular diseases; improves quality of life indicators. The positive effect of BioChaga and BioDihydroquercetin in patients with diabetes mellitus was associated with a decrease in blood sugar by 15-30%, and BioDihydroquercetin - with an increase in tissue sensitivity to glucose, and a decrease in vascular complications of diabetes mellitus. For oncological patients, BioChaga and BioDihydroquercetin are effective due to a pronounced detoxifying and protective effect. Conclusion. BioChaga and BioDihydroquercetin are natural products with proven high antioxidant, antiradical, anti-inflammatory activity. The risk factors for accelerated aging and «diseases of civilization» according to the redox theory of aging are the same. Administration of natural antioxidants BioChaga and BioDihydroquercetin is associated with a decrease in the influence of risk factors for cardiovascular, cerebrovascular, oncological diseases, diabetes mellitus, which are characteristic of «diseases of civilization»and age-associated diseases.

Keywords: 
civilization
diseases of civilization
aging
prevention
geroprotectors
antioxidants
risk factors for civilization diseases
redox theory of aging
BioChaga
BioDihydroquercetin
Baikal Legend



References: 
  1. Ponomareva N.N. The Process of Demographic Ageing: Essence, Peculiarities and Consequences in the Countries of the World. Vestnik (Herald) of the Novosibirsk State Pedagogical University. 2013; 6: 58–65.
  2. Belozerova L.M. The method of determining psychological age by the Kettell test. Gerontology and Geriatrics. 2005; 4: 96–98.
  3. Markin V.V., Markina L.D. Correlation of biological, psychological and calendar age of a person. Electronic collection of scientific works «Health and Education in the XXI Century». 2011; 13: 7.
  4. Malygina N.A. Cell aging and age-dependent diseases. Clinical Gerontology. 2014; 3–4.
  5. Titova T., Kudryashova L., Bolgova I. et al. Oxidative stress and aging: possibilities of correction. 2015; 6.
  6. Dedov D.V., Ivanov A.P., Elgardt I.A. Risk of recurrence of atrial fibrillation in patients with coronary heart disease and arterial hypertension according to Holter electrocardiogram monitoring. Bulletin of Arrhythmology. 2010; 59: 27–32.
  7. Dedov D., Mukailov N., Evtyukhin I. Combination of amlodipine and atorvastatin in reducing the risk of cardiovascular complications. Phys. 2013; 3: 18–19.
  8. Dedov D., Mukailov N., Evtyukhin I. Quality of life and prognosis in patients with AH and CHD with atrial fibrillation. Phys. 2013; 7: 72–74.
  9. Podolsky D.I., Lobanov A.V., Krukov G.V. et al. Cancer genome analysis reveals key features of human aging and its role in cancer development, Nat. Commun. 2016; 7: 12157.
  10. Dedov D., Mukailov N., Evtyukhin I. Preduktal MB in the treatment and prevention of cardiovascular complications in patients with CHD. Phys. 2013; 12: 40–41.
  11. Dedov D., Mukailov N., Evtyukhin I. Potassium and magnesium preparations in the comprehensive prevention of complications of arterial hypertension and coronary heart disease. Phys. 2013; 8: 45–46.
  12. Dedov D.V. Osteoporosis in patients of different age groups: clinical and pathogenetic aspects and treatment with Osteomed, Osteo-Vit D3 and osteomed Forte drugs. Phys. 2021; 32 (9): 64-67. DOI: 10.29296/25877305-2021-09-13.
  13. Teresa Niccoli, Linda Partridge. Ageing as a Risk Factor for Disease. L., Curr. Biol. 2012;22: R741–R752.
  14. Pristrom M.S., Sushinsky V.E., Semenenkov I.I. et al. Characteristics of the phenomenon of longevity. A look at the problem. Anti-aging medicine and medical aspects of spa. 2016.
  15. Zivkovс L., Bajiс V., Topaloviс D. et al. Antigenotoxic Effects of Biochaga and Dihydroquercetin (Taxifolin) on H2O2-Induced DNA Damage in Human Whole Blood Cells. Oxid Med Cell Longev. 2019: 5039372. DOI: 10.1155/2019/5039372.
  16. Kholyavka M.G., Rakhmanova T.I. Biomarkers of aging and new targets for anti-aging therapy. Vestnik VSU, series: chemistry, biology, pharmacy. 2020; 3.
  17. Dedov D.V. BioChaga is a freeze-dried birch mushroom chaga extract produced according to a unique author’s technology, with proven antitumor and immunomodulatory effects. Physician. 2022; (3): 78–81. https://doi.org/10.29296/25877305-2022-03-14
  18. Maksikova TM, Kalyagin AN, Usoltseva ON, et al. Possibilities of using BioDihydroquercetin for the prevention of cardiovascular diseases in elderly people engaged in health groups, Siberian Medical Journal. 2016.
  19. Vasenina E.E., Levin O.S. Oxidative stress in the pathogenesis of neurodegenerative diseases: therapy options. Modern therapy in psychiatry and neurology. 2013; 3–4.
  20. Pyrkov V., Konstantin Avchaciov, Andrei E. Tarkhov et al. Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit Timothy, Nat Communun 12, 2765 (2021).
  21. Vijg J., Campisi J. Nature. 2008. V. 454 (7208). P. 1065–1071.
  22. Joseph Panno. AGING: Theories and Potential Therapies. 2005. 157 р. 82.
  23. Usoltseva O.N., Olennikov D.N., Potupchik T.V. Evaluation of the quality and biological activity of the «BioChaga» birch fungus extract. Farmatsiya, 2022; 71 (2): 33–40.
  24. Ganov D. Use of high-quality natural dietary supplements as accompanying therapy in patients during radical radiotherapy and chemotherapy for urological cancer. Vrach. 2021; 32 (11): 76–79.
  25. Khabibulina M. State of the vascular bed in women with arterial hypertension and dyslipidemia in premenopause with estrogen deficiency. Phys. 2013 № 12. С. 31-36.
  26. Khabibulina M.M. Indices of the structural and functional state of the vascular bed in women with arterial hypertension during premenopause. Therapeutic archive. 2011 Т. 83 № 12. С. 11-15.
  27. Khabibulina M.M. Detection of painless myocardial ischemia at the outpatient stage in women with arterial hypertension and cardialgia in premenopause. Russian Journal of Cardiology. 2011.
  28. Т. V. Sinkina, Biodihydroquercetin (BDK) and Biochaga (BC) as an accompanying therapy in chemotherapy and postoperative course of distant radiation therapy for breast cancer. J. Medicine: Targeted Projects №36, 2020