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Modern ideas about the development of atherosclerosis

DOI: https://doi.org/10.29296/25879979-2024-03-06
Issue: 
3
Year: 
2024

E.M. Askerov, V.A. Utkina, A.S. Filich, Ye.A. Fisyuk
Tver State Medical University of the Ministry of Health of the Russian Federation, Tver e-mail: [email protected]

Currently, in the leading countries of the world there is a question of a significant increase in diseases associated with circulatory system disorders, but this issue should be considered together with another pathology – atherosclerosis. Analysis of modern scientific literature has shown that at the moment there is no single theory of the origin of atherosclerosis, because this disease can be caused by various factors, both endo- and exogenous. Currently, most scientists and doctors agree that atherosclerosis is a multifactorial disease, in the development of which there are complex, often long-term violations of immunologic, molecular-genetic, biochemical reactions. Many significant structural units are involved in the process of atherogenesis: the vascular wall, local disturbance of blood flow, and blood forming elements. Opinions on the etiology of atherosclerosis vary. However, most authors tend to consider dyslipidemia as the leading mechanism of atherosclerosis development; at the same time, we should not forget other possible causes of its formation.
Keywords: 
atherosclerosis
atherogenesis
etiology
pathogenesis
theory of occurrence.

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