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On the possibility of using cell technologies in surgical practice.

DOI: https://doi.org/10.29296/25879979-2024-04-06
Issue: 
4
Year: 
2024

A.M. Morozov, E.U. Aslakhanova, K.R. Ispieva
FSBEI НЕ Tver SMU МОН Russia, Tver

Cell therapy is one of the promising areas of modern medicine. This field has become widespread in many medical specialties, but over the past few years, cell therapy has been attracting more and more attention from specialists in the surgical field. Special attention is paid to therapy based on the use of stem cells, which is explained by their ability to self-renew and differentiate. Due to their properties, stem cells directly act in the wound site, triggering tissue regeneration mechanisms, and some types of stem cells suppress inflammation processes. In surgical practice, the following stem cells are used to correct skin defects and treat wounds: mesenchymal stem cells, induced pluripotent stem cells and embryonic stem cells, keratinocytes and fibroblasts. Each type of cell has its own advantages and is used in different directions. Many studies indicate the prospects of using cellular technologies in the treatment of diseases and wounds of various etiologies.
Keywords: 
cell technologies
cell therapy
stem cells
wounds
bacteriophages.

References: 
  1. Yunusov A.I., Shaimonov A.H., Karimzoda B.D. and others. The current state and prospects of using autologous cells in surgery and traumatology. Bulletin of the Academy of Medical Sciences of Tajikistan. 2020; 10 (1(33): 78–86.DOI: 10.31712/2221-7355-2020-10-1-78-86
  2. Nourian Dehkordi A., Mirahmadi Babaheydari F., Chehelgerdi M., Raeisi Dehkordi S. Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies. Stem Cell Res Ther. 2019; 10 (1): 111. DOI: 10.1186/s13287-019-1212-2.
  3. Dekoninck S., Blanpain C. Stem cell dynamics, migration and plasticity during wound healing. Nat Cell Biol. 2019; 21 (1): 18–24. DOI: 10.1038/s41556-018-0237-6
  4. Zhao Y., Wang M., Liang F., Li J. Recent strategies for enhancing the therapeutic efficacy of stem cells in wound healing. Stem Cell Res Ther. 2021; 12 (1): 588. DOI: 10.1186/s13287-021-02657-3
  5. Muromtseva E.V., Sergatsky K.I., Nikolsky V.I. and others. Wound treatment depends on the phase of the wound process. News of universities. The Volga region. Medical sciences. 2022; 3 (63). DOI: 10.21685/2072-3032-2022-3-9
  6. Gilevich I.V., Shubrov E.N., Bogdanov S.B. and others. The use of cellular technologies in the complex treatment of non-healing trophic ulcers of the lower extremities. Plastic surgery and aesthetic medicine. 2020; 3: 53–59. DOI:10.17116/plast.hirurgia202003153
  7. Hoang D.M., Pham P.T., Bach T.Q. et al. Stem cell-based therapy for human diseases. Signal Transduct Target Ther. 2022; 7 (1): 272. DOI: 10.1038/s41392-022-01134-4
  8. Bogdanov S.B., Karakulev A.V., Polyakov A.V. and others. Improving the integrated application of cell therapy and biological wound coatings in the treatment of patients with skin defects. Plastic surgery and aesthetic medicine. 2019; 4: 43–49. DOI: 10.17116/plast.hirurgia201904143
  9. Wagner D.O., Zinoviev E.V., Krylov K.M., etc. Clinical experience of allogeneic fibroblasts in patients with extensive skin burns. Bulletin of the I.I. Mechnikov Northwestern State Medical University. 2018; 10 (3): 65–72. DOI: 10.17816/mechnikov 201810365-72
  10. Vasanthan J., Gurusamy N., Rajasingh S. et al. Role of Human Mesenchymal Stem Cells in Regenerative Therapy. Cells. 2020; 10 (1): 54. DOI: 10.3390/cells10010054
  11. Fu X., Liu G., Halim A. et al. Mesenchymal Stem Cell Migration and Tissue Repair. Cells. 2019; 8 (8): 784. DOI: 10.3390/cells8080784
  12. Kraynyukov P.E., Artsimovich I.V., Zinoviev E.V. et al. The use of cellular technologies in the treatment of wounds of various etiologies. Bulletin of the National Medical and Surgical Center named after N. I. Pirogov. 2021; 2. DOI: 10.25881/20728255_2021_16_2_132
  13. Mishra V.K., Shih H.H., Parveen F. et al. Identifying the Therapeutic Significance of Mesenchymal Stem Cells. Cells. 2020; 9 (5): 1145. DOI: 10.3390/cells9051145
  14. Munir F., Jamshed M.B., Shahid N. et al. Current status of diagnosis and Mesenchymal stem cells therapy for acute pancreatitis. Physiol Rep. 2019; 7 (21): e14170. DOI: 10.14814/phy2.14170
  15. Murzich A. Autologous mesenchymal stem cells for the treatment of osteonecrosis of the femoral head. Science and innovation. 2020; 6: 208. DOI: 10.29235/1818-9857-2020-6-78-83
  16. Dupont G., Yilmaz E., Loukas M. et al. Human embryonic stem cells: Distinct molecular personalities and applications in regenerative medicine. Clin Anat. 2019; 32 (3): 354–360. DOI: 10.1002/ca.23318
  17. Zakrzewski W., Dobrzynski M., Szymonowicz M., Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther. 2019; 10 (1): 68. DOI: 10.1186/s13287-019-1165-5
  18. Griffin M.F., desJardins-Park H.E., Mascharak S. et al. Understanding the impact of fibroblast heterogeneity on skin fibrosis. Dis Model Mech. 2020; 13 (6): dmm044164. DOI: 10.1242/dmm.044164
  19. Shpichka A., Butnaru D., Bezrukov E.A. Skin tissue regeneration for burn injury. Stem Cell Res Ther. 2019; 10 (1): 94. DOI: 10.1186/s13287-019-1203-3
  20. Yamanaka S. Pluripotent Stem Cell-Based Cell Therapy-Promise and Challenges. Cell Stem Cell. 2020; 27 (4): 523–531. DOI: 10.1016/j.stem.2020.09.014
  21. Karagiannis P., Takahashi K., Saito M. et al. Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development. Physiol Rev. 2019; 99 (1): 79–114. DOI: 10.1152/physrev.00039.2017.
  22. Liu G., David B.T., Trawczynski M., Fessler R.G. Advances in Pluripotent Stem Cells: History, Mechanisms, Technologies, and Applications. Stem Cell Rev Rep. 2020; 16 (1): 3–32. DOI: 10.1007/s12015-019-09935-x.
  23. Andrews P.W. Human pluripotent stem cells: tools for regenerative medicine. Biomater Transl. 2021; 2 (4): 294–300. DOI: 10.12336/biomatertransl.2021.04.004
  24. Beschastnov V.V., Ryabkov M.G., Leontiev A.E. et al. Viability of bacteriophages in the complex hydrogel wound dressings in vitro. Sovremennye tehnologii v medicine. 2021; 13 (2): 32–39 DOI: 10.17691/stm2021.13.2.03
  25. Morozov A.M. Evaluation of the effectiveness of the use of bacteriophages in the conditions of the general surgical department. Horizons of Medical Science: VIII Conference of Young Scientists of the Russian Academy of Medical Sciences with International participation, Moscow, April 19–20, 2017. Volume II. Moscow: Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation, 2017; 45–46.
  26. Morozov A.M., Morozova A.D., Mokhov E.M. Polyvalent preparations of bacteriophages in the treatment of surgical infections. Student Science 2017: Proceedings of the All-Russian Scientific Forum of Students and Young Scientists with International participation, St. Petersburg, April 13-14, 2017. St. Petersburg: St. Petersburg State Pediatric Medical University» of the Ministry of Health of the Russian Federation, 2017; 196.