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Development of liver fibrosis. Present and future possibilities of correction in children

DOI: https://doi.org/10.29296/25879979-2022-08-01
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Issue: 
8
Year: 
2022

K.I. Grigorуev
N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, е-mail: [email protected]

Liver fibrosis (LF) is a natural consequence of almost all liver diseases of any etiology. Considering the pathogenesis of AF, we are faced with a number of standard stereotypical processes that unfold in the liver tissue. These are mainly processes of chronic inflammation, which are opposed by the processes of regeneration of liver tissues. The basis of the imbalance between the processes of fibrosis and regeneration is the accumulation of the extracellular matrix. Liver fibrosis in its development leads to cirrhosis of the liver, hepatocellular carcinoma, and an increase in the incidence is observed throughout the world. Although this is a genetically determined process, modifiable factors play an important role in the progression of this disease. Current evidence suggests the possibility of reversible liver fibrosis. Understanding the molecular mechanisms of AF development is a key area of work for scientists involved in the development of antifibrotic therapy. The article discusses modern views on the treatment/prevention of the disease and the prospects for influencing the processes of liver fibrosis with an emphasis on childhood.
Keywords: 
liver fibrosis
non-invasive diagnostics of liver fibrosis
antifibrotic therapy
children

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